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O the Fc area seem to be indispensable for specific effects.55,56 Sialylated IgG preferably interacts with C-type lectins like the human DC-Sign (Dendritic Cell-Specific Intercellular adhesion molecule3-Grabbing Non-integrin) or the murine homolog SignR1.57 Park et al.58demonstrated mSign-R1 expressed on microglial cells within the cerebellum, identifying microglia as a probably target for IVIG-in
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